Excretion of hydroflumethiazide in bile and urine of man

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Abstract
Biliary and urinary excretion of hydroflumethiazide (HFT) and its metabolite, 2,4-disulfamyl-5-trifluoromethylaniline (DTA), was investigated in 5 otherwise healthy patients with a T-drain in the common bile duct after cholecystectomy and choledochotomy. After a single oral dose of HFT 302–453 µmoles, a mean of 0.051% (range 0.028–0.075) of the dose was excreted in bile and 34.9% (range 23.7–45.4) in urine during the first 6 hours after administration. Biliary excretion appeared to be of minor importance in the elimination of HFT by man. DTA could not be detected in bile.