EFFECT OF AORTIC INSUFFICIENCY ON ARTERIAL BLOOD PRESSURE, CORONARY BLOOD FLOW AND CARDIAC OXYGEN CONSUMPTION1

Open Access
Publisher Website
Google Scholar
Abstract
In 8 dogs anesthetized by intravenous chloralose an acute aortic insufficiency was induced by an umbrella type of valve spreader. The left ventricular output and coronary sinus blood flow were measured by 2 rotameters. In all 8 experiments the coronary blood flow and myocardial O2 consumption increased in spite of a decrease in the mean arterial and/or diastolic arterial pressure. A stepwise increase in the severity of aortic insufficiency resulted in a stepwise decrease in mean arterial blood pressure and aortic diastolic pressure and a stepwise increase in coronary blood flow. This increase in coronary flow must be due to a decrease in the resistance of the coronary bed, since the coronary blood flow rose despite a marked drop of the aortic blood pressure.

This publication has 5 references indexed in Scilit: