Erythropoiesis in the Rat: Differential Rates of DNA Synthesis and Cell Proliferation
- 6 December 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3858) , 1132-1134
- https://doi.org/10.1126/science.162.3858.1132
Abstract
Direct in vivo estimates of DNA synthesis time in early and late erythroblasts were obtained by using the H3- and C14-thymidine double-la-beling technique. A double-emulsion autoradiographic procedure was used to resolve the two isotopes. Early erythroblasts were found to proliferate at a rate about five times that of late cells. This results primarily from a shorter mean DNA synthesis time in early cells (2.5 hours) than in late cells (6.5 hours).Keywords
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