HUMORAL NATURE OF THE URINE RESPONSE TO STIMULATION OF ATRIAL RECEPTORS

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Abstract
The diuretic response to stimulation of left atrial receptors by distending small balloons located at the pulmonary vein-left atrial junctions and the left atrial appendage was studied in anesthetized dogs in which bretylium tosylate, atenolol and atropine had been administered to effect blockade of renal nerves and to prevent increases in heart rate resulting from stimulation of atrial receptors. Distension of the balloons was not associated with significant changes in heart rate, left atrial pressure or arterial blood pressure, and resulted in increases in urine flow, decreases in urinary Na concentration and no significant changes in urinary Na excretion. The humoral mechanism seems responsible for the diuresis in response to stimulation of atrial receptors and has no significant effect on response of natriuresis known to involve a decrease in the activity of the renal nerves and hemodynamic changes associated with stimulation of atrial receptors.