Saccharomyces boulardiiStimulates Intestinal Immunoglobulin A Immune Response toClostridium difficileToxin A in Mice
Open Access
- 1 April 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (4) , 2762-2765
- https://doi.org/10.1128/iai.69.4.2762-2765.2001
Abstract
Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrentClostridium difficile colitis. The administration ofC. difficile toxoid A by gavage to S. boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P = 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels (P < 0.001). Enhancing host intestinal immune responses may be an important mechanism for S. boulardii-mediated protection against diarrheal illnesses.Keywords
This publication has 64 references indexed in Scilit:
- Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the HolotoxinJournal of Biological Chemistry, 1997
- Immune response to Clostridium difficile infectionEuropean Journal of Gastroenterology & Hepatology, 1996
- Pathogenesis of Clostridium difficile-associated diarrhoeaEuropean Journal of Gastroenterology & Hepatology, 1996
- Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic miceJournal of Applied Bacteriology, 1996
- Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.Journal of Clinical Investigation, 1994
- Elevated Levels of Serum Immunoglobulins in Asymptomatic Carriers of Clostridium difficileClinical Infectious Diseases, 1993
- Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxinThe Journal of Pediatrics, 1991
- Prevention of Clostridium difficile-induced experimental pseudomembranous colitis by Saccharomyces boulardii: a scanning electron microscopic and microbiological studyJournal of General Microbiology, 1990
- Nosocomial Acquisition ofClostridium difficileInfectionNew England Journal of Medicine, 1989
- Prevention of Clostridium difficile induced mortality in gnotobiotic mice by Saccharomyces boulardiiCanadian Journal of Microbiology, 1986