Activity of Some Enzymes Involved in Carbohydrate Metabolism in Normal and Scorbutic Guinea Pigs.

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Abstract
Liver tissue of normal guinea pigs showed a markedly greater ability to phosphorylate substrates than tissue from scorbutic guinea pigs when tissue respiration studies were carried out. The difference in kidney tissue was less marked. The O2 consumption of liver tissue increases noticeably in scurvy but there is no change in kidney. Adenosine triphosphatase activity of liver tissue was higher in the scorbutic animal as measured by the liberation of phosphate from adenosine triphosphate. Phosphorylation measurements in one group of normal animals were higher for both liver and kidney extracts than those obtained on the deficient group. This was not true of muscle extracts. In the 2d series of these measurements results for liver were the same but a higher figure was again obtained for kidney extracts from normal animals. Adolase activity did not seem to be lowered in scurvy.