The AraC Family Transcriptional Regulator Rv1931c Plays a Role in the Virulence of Mycobacterium tuberculosis
Open Access
- 1 September 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (9) , 5483-5486
- https://doi.org/10.1128/iai.72.9.5483-5486.2004
Abstract
A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis .Keywords
This publication has 22 references indexed in Scilit:
- Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene setMolecular Microbiology, 2004
- mymAoperon ofMycobacterium tuberculosis: its regulation and importance in the cell envelopeFEMS Microbiology Letters, 2003
- Mycobacterium tuberculosis Rv1395 Is a Class III Transcriptional Regulator of the AraC Family Involved in Cytochrome P450 RegulationJournal of Biological Chemistry, 2003
- Deletion of Two-Component Regulatory Systems Increases the Virulence of Mycobacterium tuberculosisInfection and Immunity, 2003
- DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosisInfection and Immunity, 2003
- DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexAMolecular Microbiology, 2002
- Mycobacterium bovis BCG recA Deletion Mutant Shows Increased Susceptibility to DNA-Damaging Agents but Wild-Type Survival in a Mouse Infection ModelInfection and Immunity, 2001
- Instability and site-specific excision of integration-proficient mycobacteriophage L5 plasmids: development of stably maintained integrative vectorsInternational Journal of Medical Microbiology, 2001
- Analysis, expression and prevalence of theMycobacterium tuberculosishomolog of bacterial virulence regulating proteinsFEMS Microbiology Letters, 1999
- rpsL+: a dominant selectable marker for gene replacement in mycobacteriaMolecular Microbiology, 1995