Neutrophil chemotaxis in patients with atopic dermatitis without infection

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Abstract
Atopic dermatitis was associated with recurrent infection and impaired neutrophil chemotaxis in some patients. In order to determine if dermatitis per se could decrease polymorphonuclear leukocyte (PMN) chemotaxis, chemotaxis in 13 patients was investigated with atopic dermatitis and no clinical or historical evidence of recurrent or severe infections. Most patients had extensive, but mild, disease. Leukocyte chemotaxis was measured by the Boyden chamber and agarose techniques. There was no difference between patient and control neutrophil chemotactic activity. Atopic determatitis is not ordinarily associated with impaired PMN chemotaxis in the absence of generalized erythroderma or increased susceptibility to infection.