Adrenoceptor blocking agents. Compounds related to metoprolol

Publisher Website
Google Scholar
Abstract
A group of compounds, structurally related to metoprolol, in which the aromatic nucleus is formally moved stepwise away from the ethanolamine side chain, was studied as adrenergic agonists and antagonists in cats. All the compounds were active on the adrenergic receptors and showed similar affinity for the affinity for the receptor regardless of the distance between the aromatic nucleus and the ethanolamine moiety. An ethereal O2 may be important for the affinity to the receptor but this O2 may not necessarily have to be located as an OCH2 group between the aromatic ring and the ethanolamine chain of the .beta.-blocker molecule.