TRANSFERRIN-MEDIATED UPTAKE OF GA-67 BY EMT-6 SARCOMA .2. STUDIES INVIVO (BALB-C MICE) - CONCISE COMMUNICATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 20  (8) , 843-846
Abstract
The EMT-6 sarcoma-like tumor of BALB/c mice can be grown as a solid subcutaneous transplantable tumor in vivo or as a monolayer culture in vitro. The uptake of 67Ga was studied by this tumor growing subcutaneously on the backs of 6-wk-old BALB/c mice. After i.v. administration of 67Ga citrate, tumor uptakes were as high as any others reported for mouse tumors. Also, for unknown reasons, there was appreciable reduction in tumor uptake with increasing amounts of 67Ga citrate, even in the .mu.Ci range. When mouse serum was prelabeled with 67Ga and then injected, the EMT-6 uptake was greater than with 67Ga administered as citrate (P < 0.02). The finding of avid 67Ga uptake in vivo helps to establish this unique in vivo/in vitro tumor system as a valid experimental model for studies regarding the mechanism of 67Ga accumulation by neoplastic tissue [for diagnostic purposes].