EFFECT OF INTERACTION OF VOLATILE ANESTHETICS AND HIGH HYDROSTATIC-PRESSURE ON CENTRAL NEURONS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 6  (1) , 75-91
Abstract
Autoactive neurons in the CNS of Helix and Aplysia were studied after exposure to several volatile anesthetics and under compression by mineral oil. Voltage clamp studies reveal that halothane will eliminate the slow inward current that underlies oscillatory activity in burster neurons, while high pressure shifts the negative resistance region of the current without causing its elimination. Simultaneous application of the anesthetic and pressure results in the loss of inward current over a time course similar to that of halothane application alone. In this system, pressure and anesthetics are probably not acting antagonistically at the site in the membrane that controls slow wave conductances.