Inhalation Studies With a Glycol Complex of Aluminum-Chloride-Hydroxide

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Abstract
Inhalation studies were performed with a propylene glycol complex of aluminum-chloride-hydroxide (alchlor), a compound found in some aerosol antiperspirant preparations. Hamsters were given either three exposures to 150 mg alchlor/cu meter or 30 exposures to 50 mg/cu meter and killed at various times for histopathological examination. The lungs of animals given 20 or more exposures to 50 mg/cu meter showed a granulomatous lesion in the respiratory bronchioles that persisted throughout a six-week postexposure period. Alveolar thickening and increased numbers of macrophages were seen in lungs of hamsters soon after three exposures to 150 mg/cu meter but with time these changes regressed. Lung weights in hamsters given three exposures to 35 mg/cu meter or higher were increased on the fourth day. Mixed function oxidase (MFO) activities of rabbit and hamster microsomes from both lung and liver were examined after three daily exposures. No changes were seen in the MFO activity of liver microsomes. Lung microsomes from exposed animals showed a decrease in specific activity (per milligram microsomal protein). However, lung weights of exposed animals were increased, and the activity per lung was similar in exposed and control animals.

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