Group‐specific component (Gc) subtypes and schizophrenia

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Abstract
Schizophrenic patients (108 males and 107 females) in north-east England, UK, were investigated for Gc [group-specific component] types and subtypes and compared with the frequencies in 1st-degree relatives and controls. Book et al. described Gc2 allele association with schizophrenia. No such association was found with the Gc2 allele in the present study although there is a tendency towards an increased frequency in females. In subtype allele frequencies the female patients showed a significant reduction of Gc1S allele. A difference in susceptibility associated with the Gc locus in patients of different sexes is suggested.