A new series of potent benzodiazepine γ-secretase inhibitors
- 7 December 2002
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 13 (2) , 179-183
- https://doi.org/10.1016/s0960-894x(02)00909-5
Abstract
No abstract availableKeywords
This publication has 16 references indexed in Scilit:
- γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?Nature Reviews Neuroscience, 2002
- Secretase Targets for Alzheimer's Disease: Identification and Therapeutic PotentialJournal of Medicinal Chemistry, 2001
- β-Amyloid therapies in Alzheimer’s diseaseExpert Opinion on Investigational Drugs, 2001
- Presenilin and γ‐secretase: structure meets functionJournal of Neurochemistry, 2001
- Quantitation of amyloid-β peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assayJournal of Neuroscience Methods, 2000
- Factors influencing the processing and function of the amyloid β precursor protein—a potential therapeutic target in Alzheimer's disease?Pharmacology & Therapeutics, 2000
- Synthesis and resolution of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-onesThe Journal of Organic Chemistry, 1987
- Crystallization-induced asymmetric transformation: stereospecific synthesis of a potent peripheral CCK antagonistThe Journal of Organic Chemistry, 1987
- Asymmetric alkylation reactions of chiral imide enolates. A practical approach to the enantioselective synthesis of .alpha.-substituted carboxylic acid derivativesJournal of the American Chemical Society, 1982
- Oxazolines. XI. Synthesis of functionalized aromatic and aliphatic acids. Useful protecting group for carboxylic acids against Grignard and hydride reagentsThe Journal of Organic Chemistry, 1974