Synthetic studies on antibiotic validamycins. Part 11. Synthesis of validamycin A
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2369-2374
- https://doi.org/10.1039/p19850002369
Abstract
The antibiotic validamycin A (1a) has been synthesized for the first time (as its undeca-O-acetate) by glycosylation of the partially protected derivative (8) of the aglycone, validoxylamine A (2a), with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride (11), followed by deprotection, thereby establishing the structure previously assigned. The totally O-acetytated derivative (19) of 7-deoxyvalidemycin A has been synthesized in a similar fashion.This publication has 2 references indexed in Scilit:
- Chemical Modification of Validamycin AAgricultural and Biological Chemistry, 1980
- STUDIES ON VALIDAMYCINS, NEW ANTIBIOTICS. IThe Journal of Antibiotics, 1970