Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine.
Open Access
- 1 January 1981
- Vol. 22 (1) , 14-18
- https://doi.org/10.1136/gut.22.1.14
Abstract
The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum greater than ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.This publication has 27 references indexed in Scilit:
- Effects of pancreatic polypeptide and vasoactive intestinal polypeptide on rat ileal and colonic water and electrolyte transportin vivoDigestive Diseases and Sciences, 1979
- Effects of gastrointestinal hormones on fasting gallbladder storage patterns in manEuropean Journal of Clinical Investigation, 1979
- Measurement of fasting and postprandial plasma VIP in man.Gut, 1978
- A Pancreatic-Polypeptide-producing Tumour Associated with the WDHA SyndromeScandinavian Journal of Gastroenterology, 1978
- Intestinal Secretion Induced by Vasoactive Intestinal PolypeptideJournal of Clinical Investigation, 1978
- Hormone-Sensitive Adenylate Cyclase in Human Colonic MucosaDigestion, 1978
- Distribution and release of human pancreatic polypeptide.Gut, 1976
- PANCREATIC POLYPEPTIDE IN INSULINOMAS, GASTRINOMAS, VIPOMAS, AND GLUCAGONOMASThe Lancet, 1976
- Vasoactive Intestinal Peptide Stimulation of Adenylate Cyclase and Active Electrolyte Secretion in Intestinal MucosaJournal of Clinical Investigation, 1974
- Intestinal Secretion: Stimulation by PeptidesScience, 1971