Antirabic Vaccination—Present Status

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Abstract
This paper presents further confirmatory data on the new quantitative method of measuring the immunizing potency of antirabic vaccines. Mice are vaccinated and then given graded doses of a virulent rabies virus 3 weeks later. It was found that formalized vaccines did not protect the mice but that vaccines treated with chloroform were effective provided 2 times the stated dose was given. Findings in dogs parallelled these results. Exposure to u.-v. killed the virus but did not lessen its immunizing potency. Suitably irradiated vaccines protected mice against 10-100 intracerebral or 32-64 intra-musc. doses of virulent virus.

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