Metoclopramide as an Antiemetic in Chemotherapy

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Abstract
To the Editor: Several papers have been published recently on the usefulness of metoclopramide as an antiemetic in chemotherapy, and a point mentioned by both Gralla et al.1 and Laszlo and Lucas2 (October 15 issue) deserves emphasizing. Although metoclopramide is highly effective against cisplatin, the most emetogenic chemotherapeutic agent to date, it should not be assumed that metoclopramide will be the antiemetic of choice for all chemotherapy-induced nausea and vomiting.There is mounting evidence that chemotherapeutic agents trigger emesis via different or multiple pathways.3 Studies in dogs4 have suggested that a peripheral pathway is the most likely mechanism responsible for . . .