The Incidence and Severity of Atherosclerosis in Estrogen-Treated Males, and in Females with a Hypoestrogenic or a Hyperestrogenic State

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Abstract
The incidence and severity of atherosclerosis as noted at postmortem examination were compiled in a group of patients who had abnormalities in estrogen supply consisting of: (1) males with prostatic cancer treated with large estrogen doses; (2) males with prostatic cancer treated with small estrogen doses; (3) females castrated surgically before the normal menopause; and (4) hyperestrogenic females with carcinoma of the breast. The findings were then compared with those in persons whose estrogen status was normal. Excessive estrogen decreases the incidence of severe atherosclerosis in both males and females; diminished estrogen production in the female renders her more susceptible to severe atherosclerosis.