MECHANISM OF AMINOACYL RNA SYNTHESIS: STUDIES WITH ISOLATED AMINOACYL ADENYLATE COMPLEXES OF ISOLEUCYL RNA SYNTHETASE
- 1 August 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 52 (2) , 330-337
- https://doi.org/10.1073/pnas.52.2.330
Abstract
Highly purified isoleucyl-RNA synthetase from Escherichia coli forms both enzyme-isoleucyl adenylate and enzyme-valyl adenylate complexes. Both isolated complexes react with inorganic pyrophosphate to form adenosine-triphosphate (ATP). Only the isoleucyl adenylate complex transfers its aminoacyl moiety to t-RNA. Transfer RNA containing active isoleucine-specific chains induces breakdown of the enzyme-valyl adenylate complex.This publication has 12 references indexed in Scilit:
- Observations on the configuration of nucleotides near the 3′-hydroxy end of adapter RNABiochemical and Biophysical Research Communications, 1964
- STUDIES OF ACETYL COENZYME A SYNTHETASE REACTION .1. ISOLATION AND CHARACTERIZATION OF ENZYME-BOUND ACETYL ADENYLATE1963
- A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein MixturesJournal of Biological Chemistry, 1961
- ENZYMIC SYNTHESIS OF AMINO ACYL DERIVATIVES OFRIBONUCLEIC ACID .4. FORMATION OF 3'-HYDROXYL TERMINAL TRINUCLEOTIDE SEQUENCE OF AMINO ACID-ACCEPTOR RIBONUCLEIC ACID1961
- Enzymatic Synthesis and Reactions of Amino Acyl AdenylatesJournal of Biological Chemistry, 1960
- THE CHEMICAL NATURE OF THE RNA-AMINO ACID COMPOUND FORMED BY AMINO ACID-ACTIVATING ENZYMESProceedings of the National Academy of Sciences, 1959
- The Synthesis and Function of Luciferyl-adenylate and Oxyluciferyl-adenylateJournal of Biological Chemistry, 1958
- Studies on the Enzymatic Utilization of Amino Acyl Adenylates: the Formation of Adenosine TriphosphateJournal of Biological Chemistry, 1958
- An Enzymatic Mechanism for Linking Amino Acids to RNAProceedings of the National Academy of Sciences, 1958
- ACYL ADENYLATES: THE INTERACTION OF ADENOSINE TRIPHOSPHATE AND l-METHIONINEJournal of Biological Chemistry, 1956