Analysis of the nucleotide sequence of an invertible controlling element.
- 1 July 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (7) , 4196-4200
- https://doi.org/10.1073/pnas.77.7.4196
Abstract
The nucleotide sequence of the inversion region responsible for flagellar phase variation in Salmonella was determined. The inversion region is 995 base pairs (bp) in length and is bounded by a 14-bp inverted repeat sequence. A homologous recombination event between the 14-bp inverted repeat sequences would result in the inversion of the DNA segment between them. Sequence homologies with other systems suggest that the 14-bp inverted repeat sequences may have some general significance as sites for specific recombinational events. The gene which specifies H2 flagellin synthesis begins 16 bp outside the inversion region. Within the inversion region, an open translational frame exists which could encode a low MW polypeptide (190 amino acids).This publication has 30 references indexed in Scilit:
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