1,10-Phenanthroline Potentiates Cytotoxicity of Hydroxyurea in Human Chronic Myeloid Leukemia Cells
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 46 (3) , 193-197
- https://doi.org/10.1159/000226713
Abstract
The effect of the divalent hydrophobic metal chelator 1,10-phenanthroline was evaluated alone and in combination with the antineoplastic agent hydroxyurea on human chronic myeloid leukemia cells. The compound at concentrations of 10 and 5 μg/ml significantly (p +2 and Zn. The results strongly suggest the utility of the iron-chelating agent along with hydroxyurea for further evaluation to achieve a better therapeutic result in the clinic.Keywords
This publication has 11 references indexed in Scilit:
- Application of Radioactive Precursors for the Evaluation of Sensitivity of Cancer Cells to Anticancer DrugsOncology, 1984
- In vitro Enhancement of Adriamycin Cytotoxicity in Human Myeloid Leukemia Cells Exposed to VerapamilOncology, 1984
- Characterization of the free radical of mammalian ribonucleotide reductase.Journal of Biological Chemistry, 1982
- Effect of iron-chelating agents on inhibitors of ribonucleotide reductaseBiochemical Pharmacology, 1981
- Effect of various iron chelating agents on DNA synthesis in human cellsBiochemical Pharmacology, 1980
- Degradation of DNA by 1,-10-phenanthrolineBiochemical and Biophysical Research Communications, 1980
- Control of growth by picolinic acid: Differential response of normal and transformed cellsProceedings of the National Academy of Sciences, 1977
- Studies on the acid-soluble nucleotide pool in Escherichia coliBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967
- Hydroxyurea inhibition of DNA synthesis in ascites tumor.Proceedings of the National Academy of Sciences, 1965
- RAPID MEMBRANE FILTRATION TECHNICS FOR STUDYING ACTION OF 6-THIOGUANINE ON TUMOR CELLS IN VITRO1963