The Leukemic Phase of Histiocytic Lymphoma: Histologic, Cytologic, Cytochemical, Ultrastructural, Immunologic and Cytogenetic Observations in a Case

Abstract
Brynes, Russell K., Golomb, Harvey M., Gelder, Frank, Desser, Richard K., and Rowley, Janet: The leukemic phase of histiocytic lymphoma. Histologic, cytologic, cytochemica), ultrastructural, immunologic and cytogenetic observations in a case. Am J Clin Pathol 69: 550–558, 1978. A case of histiocytic lymphoma that progressed to a leukemic phase was studied by various methods. Although the cells were found to bear a superficial morphologic resemblance to histiocytes, they more closely resembled transformed lymphocytes. Immunologic markers strongly supported a B-lymphoid origin in this case, while cytogenetic analysis indicated a large number of consistent chromosomal rearrangements, including a translocation involving chromosomes Nos. 8 and 14 which has been previously reported to occur primarily in Burkitt’s lymphoma.