Spectrophotometric determination of isoniazid in excess p-aminosalicylate
- 1 October 1964
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 16 (10) , 696-699
- https://doi.org/10.1111/j.2042-7158.1964.tb07389.x
Abstract
The presence of a large excess of p-aminosalicylic acid prevents the direct application of Vierordt’s spectrophotometric method to the determination of isoniazid in tablets. The method can, however, be applied after the bulk of the p-aminosalicylic acid has been removed with ether. The extinction of the aqueous phase containing all the isoniazid and some of the p-aminosalicylic acid is then determined at two wavelengths and the concentration of isoniazid calculated therefrom.Keywords
This publication has 4 references indexed in Scilit:
- A Modified Procedure for the Determination of Isoniazid in Mixtures with Sodium p-AminosalicylateJournal of Pharmacy and Pharmacology, 1962
- The Importance of Extinction Ratios in the Spectrophotometric Analysis of Mixtures of Two Known Absorbing SubstancesJournal of Pharmacy and Pharmacology, 1960
- The Determination of Isoniazid in Pharmaceutical Preparations Containing Sodium p-AminosalicylateJournal of Pharmacy and Pharmacology, 1957
- A Criterion of Convergence for the Classical Iterative Method of Solving Linear Simultaneous EquationsThe Annals of Mathematical Statistics, 1945