THE ROLE OF THYRONINE IN THYROID HORMONE METABOLISM
- 1 October 1979
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 49 (4) , 658-660
- https://doi.org/10.1210/jcem-49-4-658
Abstract
Thyronine (TO) has been identified in human urine using gas chromatography-mass fragmentography (G.C.M.F.). In 22 normal individuals urinary TO concentration was found to range between 8-25 nmol⁄24h. Assuming the mean normal thyroxine (T4) production rate to be approximately 100 nmol⁄24h, our findings indicate that less than 20% of this could be accounted for as urinary TO excretion, thus supporting earlier findings that the peripheral metabolism of T4 is not limited solely to deiodination.Keywords
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