Carbohydrate Metabolism in Ascorbic Acid Deficiency

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Abstract
Insulin tolerance tests on ascorbic acid-deficient and pair-fed control guinea pigs indicated that a progressive resistance to the hypoglycemic action of insulin accompanies ascorbic acid-deficiency. This observation was confirmed by glucose-insulin tolerance tests. Glucose-insulin tolerance tests on ascorbic acid-deficient and pair-fed control adrenalectomized guinea pigs demonstrated that the insulin resistance of ascorbic acid-deficiency is independent of the adrenal cortex, as it is of insulin. Data indicate that the carbohydrate disturbance in ascorbic acid-deficiency is probably not due to diminished insulin secretion, and is not ascribable to adrenal hyperactivity. The carbohydrate utilization technique on such animals indicated that glycogenesis is decreased in scurvy.