Serum IgE in Primary Glomerular Diseases

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Abstract
Serum IgE was measured by RIST [radioimmunosorbent test] test in 181 adult subjects, with log transformation. In 24 controls the geometric mean was 109 IU/ml, with an upper limit (geometric mean .+-. 2 SD) of 460 IU/ml. Cases (157) of glomerulonephritis (GN) classified according to light and immunofluorescence microscopy were studied. Serum IgE was significantly elevated in 39 lipoid nephrosis patients (P < 0.001, with 21 levels > 460 IU/ml), 21 focal and segmental glomerulosclerosis (P < 0.05, with 8 levels > 460 IU/ml) and 42 membranous GN (P < 0.01, with 10 levels > 460 IU/ml). In 27 membranoproliferative GN and 28 IgA GN, serum IgE was not different from controls with respectively 4 and 3 levels > 460 IU/ml. The lipoid nephrosis IgE geometric mean is 493 IU/ml, which is in keeping with the high incidence of atopic troubles. The significance of raised serum IgE was discussed.