Double‐blind randomized controlled trial of isoxicam vs piroxicam in elderly patients with osteoarthritis of the hip and knee.

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Abstract
1 Fifty‐seven elderly patients with primary osteoarthritis of the hip and knee were entered into a double‐blind, randomized, controlled parallel group trail to compare the efficacy and tolerability of isoxicam (maximum = 200 mg day‐1) and piroxicam (maximum = 20 mg day‐ 1). 2 Clinical assessments were made following a 1 week NSAID‐free washout period and at biweekly intervals during the next 6 weeks of active treatment. 3 The majority of patients in both groups experienced a clinically important and statistically significant therapeutic response. 4 No statistically significant between‐group differences were noted with respect to drug efficacy. 5 One patient was withdrawn from the piroxicam group because of lack of effect, but there were no such withdrawals from the isoxicam group. 6 Five patients were withdrawn from the piroxicam group because of adverse reactions compared to only one withdrawal from the isoxicam group. 7 This study indicates that isoxicam is an efficacious and well‐tolerated once‐daily NSAID for elderly patients with osteoarthritis.

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