Quantitative Study of the Response to LH After Hypophysectomy in the Ovarian Ascorbic Acid Depletion Test: Effect of Prolactin

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Abstract
In the ovarian ascorbic acid test for LH in the rat, the ascorbic acid content of the luteinized ovary falls markedly as early as 4½ hr after hypophysectomy. This hypophysectomized animal does not respond any more to doses of LH active in the normal animal. The administration of (ovine) prolactin at the time of hypophysectomy maintains the content of ovarian ascorbic acid and the responsivity to LH.