ORs Rule the Roost in the Olfactory System
- 19 December 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5653) , 2078-2079
- https://doi.org/10.1126/science.1093397
Abstract
It is well established that each olfactory neuron of the mammalian olfactory system expresses only one olfactory receptor (OR) out of the 1000 OR proteins encoded by the mammalian genome. In their Perspective, Lewcock and Reed discuss new findings ( Serizawa et al.) that show how the OR protein itself participates in a negative feedback mechanism, which ensures that only one OR is expressed in each olfactory neuron.Keywords
This publication has 13 references indexed in Scilit:
- Negative Feedback Regulation Ensures the One Receptor-One Olfactory Neuron Rule in MouseScience, 2003
- DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene RegulationScience, 2003
- Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2Science, 2003
- The olfactory receptor gene superfamily of the mouseNature Neuroscience, 2002
- Mutually exclusive expression of odorant receptor transgenesNature Neuroscience, 2000
- YAC transgene-mediated olfactory receptor gene choiceDevelopmental Dynamics, 2000
- Visualizing an Olfactory Sensory MapCell, 1996
- Allelic inactivation regulates olfactory receptor gene expressionCell, 1994
- Spatial segregation of odorant receptor expression in the mammalian olfactory epitheliumCell, 1993
- A zonal organization of odorant receptor gene expression in the olfactory epitheliumCell, 1993