Effect of PGF-2 on uterine activity, and concentrations of 13,14-dihydro-15-keto-PGF-2 in peripheral plasma during parturition in the tammar wallaby (Macropus eugenii)

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Abstract
I.v. administration of PG[prostaglandin]F2.alpha. or an analog stimulated uterine contractility in gravid uteri during seasonal quiescence and late pregnancy. The exogenous PGF2.alpha. was metabolized to 13,14-dihydro-15-keto-PGF2.alpha. (PGFM) which was assayed in peripheal plasma by a radioimmunoassay. PGFM was cleared from the circulation with a half-life of 8-15 min. Blood samples were taken approximately every 6 h from day 26 to day 30 from tammars which were expected to give birth on day 27-28. Basal levels of PGFM were < 400 pg/ml, and only occasional samples contained higher PGFM concentrations. If uterine PGF2.alpha. release is elevated at parturition in tammars, the corresponding rise of circulating PGFM is either small or of short duration.