Regional Amino Acid Concentration in the Brains of Rats Exposed to High Pressures
- 1 July 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 47 (1) , 314-317
- https://doi.org/10.1111/j.1471-4159.1986.tb02864.x
Abstract
Regional amino acid concentrations were measured in rat brain fixed by microwave irradiation at three levels of elevated atmospheric pressure corresponding to different phases of the high-pressure neurological syndrome [20 atmospheres absolute (ATA), no clinical signs; 60 ATA, tremor; 85 ATA, severe tremor and myoclonic jerks]. No changes in amino acid content occurred at 20 or 60 ATA. At 85 ATA glutamine content increased in hippocampus, striatum, cerebellum, and substantia nigra, and γ-aminobutyric acid content increased in hippocampus. It is suggested that enhanced glutamate release in various subcortical structures contributes to the myoclonic activity observed at 85 ATA.Keywords
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