Effect of Growth Hormone Preparations on Cardiac Hypertrophy and Blood Pressure of Hypophysectomized Rats

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Abstract
Of three growth hormone preparations only one (PGH 163-208A, Armour) restored cardiac hypertrophy and hypertension on aortic constriction in hypophysectomized rats near to the level seen in normal rats. The same aortic constriction caused no increase in the weight of the heart and no hypertension in untreated hypophysectomized rats and in similar rats treated with a bovine growth hormone preparation (R 285-174, Armour) or crystalline growth hormone (Dr. Li, Berkeley). The different action of the three preparations was not connected with their effect on appetite and on body growth. ACTH, 5 mg/rat/day, caused adrenal hypertrophy in hypophysectomized rats without raising their blood pressure. The weight of the heart and particularly the blood pressure after aortic constriction were, however, greater in hypophysectomized rats treated with ACTH than in their nontreated controls.