Vitamin A and Cholesterol Absorption in the Chicken

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Abstract
The administration of large amounts of vitamin A to 6- to 7-week-old chickens reduced the increase in serum cholesterol level resulting from the inclusion of 1% of cholesterol in the diet. Vitamin A did not, however, moderate the hyperlipemia and hypercholesterolemia produced in birds fed a low cholesterol diet and treated with diethylstilbestrol. Large doses of vitamin A reduced the level of cholesterol in the intestinal wall and in the liver of birds fed 1% of cholesterol. Conversely, birds receiving large amounts of vitamin A and 1% of cholesterol in the diet did not store as much vitamin A in the liver as birds receiving the same amount of vitamin A in conjunction with a diet low in cholesterol. It is concluded that there is mutual interference between vitamin A and cholesterol during the course of absorption across the intestinal wall.