Anaerobic leakage of potassium from brain

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Abstract
Changes in the concn. of K in bicarbonate-Ringer bathing slices of rabbit cerebral cortex were determined. During anaerobic metabolism in the presence of glucose, there was no increase in K; in the absence of glucose, there was a significant rise. The action of glucose in preventing this loss of K is dynamic; it depends on the active utilization of glucose by the glycolyzing cell. Where glycolysis was inhibited by fluoride, K leaked into the environmental fluid just as in the absence of glucose. Brain thus resembles red blood cells.