Pulmonary Infarction and Atrophy of the Spleen Associated with Sickle-Cell Hemoglobin C Disease

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Abstract
ALTHOUGH sickle-cell disease has been associated with vascular thrombosis and tissue infarction1 sickle states have only recently been associated with similar phenomena. Splenic infarctions,2 3 4 5 pulmonary infarctions,7 cerebral thrombosis,8 maternal deaths,6 bony changes9 and hematuria10 , 11 are some of the phenomena occurring with sickle states. The purpose of this paper is to recognize the potential dangers associated with sickle states and to report the occurrence of an atrophied, siderofibrotic spleen in sickle-cell hemoglobin C disease.Case ReportA 34-year-old Negro laborer was admitted to the Oakland Veterans Administration Hospital with pulmonary complaints on 5 different occasions after November 22, 1948. The only . . .