Schiff's base formation in the lens protein γ‐crystallin
- 19 September 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 161 (2) , 221-224
- https://doi.org/10.1016/0014-5793(83)81012-6
Abstract
Uniquely among the soluble lens‐specific proteins, γ‐crystallin is capable of binding the strongly chromophoric aldehyde retinal. a role for γ‐crystallin in protecting lens components from toxic aldehydes resulting from membrane oxidation is proposed and a molecular model of the probable interaction site is presented. The sequence of a tetrapeptide at this site is identical to that of the retinal binding site of bacteriorhodopsin.Keywords
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