Suppression of interstitial nephritis by auto-anti-idiotypic immunity.
Open Access
- 1 January 1982
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 155 (1) , 179-189
- https://doi.org/10.1084/jem.155.1.179
Abstract
Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.Keywords
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