Effect of Alloxan on Lactation and Replacement Therapy with Insulin in the Rat.

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Abstract
Summary Chronic diabetes was induced in rats on day 4 of lactation by intraperitoneal injection of 15 mg/100 g body weight of alloxan. The reduction in insulin secretion caused a reduction of milk secretion of 16% on day 14, of 8% on day 16, and 9% on day 18. On day 20 milk secretion was 5% above the control group. When 2 units of insulin were administered daily, milk secretion increased 45% on day 14, 21% on day 16, 22% on day 18, and 61% on day 20 in comparison with the group treated with alloxan. Their milk production slightly exceeded the production of normal animals injected with 2 units of insulin. The DNA content of the mammary glands of the 2 groups was not significantly different.

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