Release of prostaglandins from the passively distended wall of guinea pig small intestine.

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Abstract
The effects of the radial distension of the intestinal wall and the increased intraluminal pressure on the liberation of prostaglandins (PG) were studied with the isolated guinea pig ileum. Both procedures were accompanied by an increased output of a PG-like substance and the release was proportional to the degree of distension or intraluminal pressure. TLC coupled with bioassay suggested that this substance may be a mixture of PGF2.alpha., PGE2 and PGE1. The existence of the former 2 types of PG were prominent. The distension-induced release of PG-like substance was presumably not mediated by nerve excitation since tetrodotoxin failed to inhibit the release. The increased output of the PG-like substance was not maintained after distension of the intestinal wall, despite continued application of stimulus; actual tissue deformation is an essential condition leading to increased PG output. Distension of the intestinal wall to its circumferential direction is an appropriate stimulus for the release of PG-like substance from the small intestine. PG may participate in the peristaltic activity.