Central nervous system effects of arachidonic acid, PGE2, PGF2α, PGD2 and PGI2 on gastric secretion in the rat

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Abstract
1 The effects of arachidonic acid, prostaglandin E2 (PGE2), PGF2α, PGD2 and PGI2 on gastric secretion (acid, pepsin and volume) after intracerebroventricular administration were investigated in conscious, pylorus-ligated rats. 2 Arachidonic acid 30–1000 μg had no effect on gastric secretion. 3 PGE2 3 and 10 μg, reduced gastric secretion as measured 1 hour after injection, although the inhibition induced by 3 μg disappeared by 2 h. 4 PGF2α 10 and 30 μg, inhibited gastric secretion as measured after 1 h, whereas no change was observed in the gastric contents collected 2 h after 10 μg of PGF2α. Intramuscular injection of 30 μg of PGF2α had no effect on gastric secretion. 5 Intracerebroventricular administration of 1–30 μg of PGD2 or PGI2 had no effect on gastric secretion. 6 The results indicate that PGE2 and PGF2α have a potent central antisecretory action in conscious, pylorus-ligated rats, whereas arachidonic acid, PGD2 and PGI2 do not have any central effects on gastric secretion. It is suggested that PGE2 and PGF2α may be involved in the central nervous system control of gastric secretion.

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