Characterization of an Indian (δβ)° thalassaemia
- 1 October 1984
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 58 (2) , 353-360
- https://doi.org/10.1111/j.1365-2141.1984.tb06094.x
Abstract
The molecular basis of .delta..beta. thalassemia in an Indian family is shown here to be due to a previously undescribed deletion within the .beta. globin gene complex. Starting 3 kilobases from the 3'' end of the A.gamma. gene, the deletion removes the .delta. and .beta. globin genes, and continues to an unknown extent in the 3'' direction. Heterozygotes for this deletion have .apprx. 25% Hb F with a G.gamma.:A.gamma. ratio of 70:30, while interaction with .beta.+ thalassemia results in the clinical picture of thalassemia intermedia.This publication has 15 references indexed in Scilit:
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