THE CHOLESTEROL AND ASCORBIC ACID CONTENT OF THE ADRENAL, LIVER, BRAIN, AND PLASMA FOLLOWING HEMORRHAGE

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Abstract
Following a non-fatal hemorrhage both the cholesterol and ascorbic acid content of the adrenals of the rat are decreased. The fall in ascorbic acid precedes that of cholesterol, and it is restored more rapidly during the recovery period. The time relationships of these changes in the adrenal are similar to those following injn. of adrenotrophic hormone into intact rats. Hypophysec-tomy prevents these alterations in adrenal cholesterol and ascorbic acid after bleeding. Shock induced in rats by hemorrhage is associated with marked depletion of adrenal cholesterol and ascorbic acid, and there is no tendency for recovery in the levels of these substances before death. The cholesterol content of the liver and brain are unaffected by either fatal or non-fatal hemorrhage. The plasma cholesterol falls during shock due to hemorrhage. The ascorbic acid of the liver rises after a non-fatal hemorrhage but is markedly decreased in shock due to hemorrhage. The plasma ascorbic acid rises slightly after non-fatal hemorrhage and is increased 6-fold in shock. The levels in the brain are unaffected. It is suggested that the alterations in adrenal cholesterol and ascorbic acid are associated with the secretion of the cortical hormones and that they participate in their formation.

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