Adrenal Medullary Stimulating Action of Tetraethylammonium.

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Abstract
Summary The injection of .25 to 4 mg of TEA into the blood supplying the adrenal gland of cats with restricted circulation caused definite pressor effects and contraction of the nictitating membrane. The same amounts injected into the jugular vein were without effect. Since adrenalectomy or administration of adrenergic blocking agents abolished the responses, it is concluded that the effects observed were probably due to epinephrine and/or nor-epinephrine released from the adrenal medulla. It is suggested that this simulated nicotinic action is responsible for the pressor effects of TEA that are observed in man and animals under the conditions discussed.

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