Localization of 8-Methoxypsoralen in Ocular Tissues

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Abstract
UVA radiation results in the generation of 8-methoxypsoralen (8-MOP) photoproducts which can be permanently retained in the rat and dogfish lenses and retinas as demonstrated by phosphorescence and EPR spectroscopy, autoradiography and radioactivity of labeled products in these tissues. 8-MOP photoproducts also develop in the corneal epithelium but these cells are replaced within 3–4 days. These experiments suggest that photobound 8-MOP products could accumulate in human lenses and in aphakic or young retinas. Such photoproducts can be prevented by proper UV filtering glasses worn for at least 24 h after ingestion of 8-MOP.