Acute toxic liver injury. nicotinamide-adenine dinucleotide-pyrophosphorylase activity of nuclei isolated from rat liver in heliotrine and in dimethylnitrosamine poisoning

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Abstract
Nicotinamide-adenine dinucleotide-pyrophosphorylase activity of preparations of nuclei isolated from the livers of control and heliotrine-treated Wistar rats and of control and dimethylnitrosamine-treated Sprague-Dawley rats has been estimated. The activity as detected by the rate of nicotinamide-adenine dinucleotide synthesis was significantly decreased below the control level in liver-cell nuclei isolated from rats which had been treated with heliotrine for 18 hr. (or more). There was no significant decrease in rate in the liver nuclei from the rats treated with dimethylnitrossamine (19 hr.) relative to nuclear count. The observations are discussed in relation to present knowledge of nicotinamide-adenine dinucleotide metabolism in liver poisoning.