Effect of vagotomy on secretin and pancreozymin activity of intestines of albino rats

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Abstract
Crude HCl extracts were made from the intestines of vagotomized albino rats and their paired fed controls. Using a simple cross-over design requiring two rabbits for each assay, the extracts were compared for secretin and pancreozymin activity. Significant differences in both the volume and amylase activity of the pancreatic juice secreted in response to 5-ml injections of the extracts were observed. It was concluded that vagotomy led to a reduction in the secretin activity, but an increase in the pancreozymin activity of the intestines.