Abstract
The protein of TMV is denaturated after extraction by phenol, precipitation with methanol and resolution in 0.1 M NaOH or 8 M urea. The denaturated protein could be transformed to the native state. The following criteria were used for the differentiation between the denaturated and the native state: solubility in neutral aqueous medium, aggregation to regular viruslike rods, reconstitution to infectious virus with ribonucleic acid and the serological specificity.

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