Nuclear organization of the genome and the potential for gene regulation
Top Cited Papers
- 23 May 2007
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 447 (7143) , 413-417
- https://doi.org/10.1038/nature05916
Abstract
Much work has been published on the cis-regulatory elements that affect gene function locally, as well as on the biochemistry of the transcription factors and chromatin- and histone-modifying complexes that influence gene expression. However, surprisingly little information is available about how these components are organized within the three-dimensional space of the nucleus. Technological advances are now helping to identify the spatial relationships and interactions of genes and regulatory elements in the nucleus and are revealing an unexpectedly extensive network of communication within and between chromosomes. A crucial unresolved issue is the extent to which this organization affects gene function, rather than just reflecting it.Keywords
This publication has 44 references indexed in Scilit:
- Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactionsNature Genetics, 2006
- Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)Nature Genetics, 2006
- Genome-wide scanning of HoxB1-associated loci in mouse ES cells using an open-ended Chromosome Conformation Capture methodologyChromosome Research, 2006
- Chromosome territories – a functional nuclear landscapeCurrent Opinion in Cell Biology, 2006
- Transient Homologous Chromosome Pairing Marks the Onset of X InactivationScience, 2006
- Transient colocalization of X-inactivation centres accompanies the initiation of X inactivationNature Cell Biology, 2006
- Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase RosettesPLoS Biology, 2005
- Tissue-specific spatial organization of genomesGenome Biology, 2004
- Chromosome positioning in the interphase nucleusTrends in Cell Biology, 2002
- Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human populationChromosome Research, 2002