Abstract
Highly purified preparations of the isometric mushroom viruses [MV] 1 and 4 were made by a combination of differential centrifugation, ion-exchange chromatography on DEAE-cellulose and sucrose density-gradient centrifugation. Purified preparations of MV1 virions (25 nm diameter) sedimented at 130S and contained 1 capsid polypeptide of MW 24,400 and 2 species of double-stranded RNA of MW about 1.4 .times. 106. MV4 particles (35 nm diameter) had a sedimentation value of 140-145S and contained 1 capsid polypeptide of MW 63,800 and 2 species of double-stranded RNA of MW 1.5 .times. 106 and 1.4 .times. 106. MV1 and MV4 were antigenically unrelated.

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